Micellar systems of poloxamer 407 and 403 for quercetin delivery
نویسندگان
چکیده
منابع مشابه
Micellar systems of poloxamer 407 and 403 for quercetin delivery
The use of poloxamers (PL) have been one of the most widely strategies used for drug delivery systems. The copolymer Poloxamer 407 is a non-ionic surfactant consisting of polioxyethylene (POE) and polioxypropylene (POP) that has many pharmaceutical applications due to its thermoreversible properties. PL are biocompatible and for this reason, are very attractive as carrier systems for administra...
متن کاملPoloxamer 407/TPGS mixed micelles for delivery of gambogic acid to breast and multidrug-resistant cancer
BACKGROUND Delivery of a high concentration of anticancer drugs specifically to cancer cells remains the biggest challenge for the treatment of multidrug-resistant cancer. Poloxamers and D-α-Tocopheryl polyethylene glycol 1000 succinate (TPGS) are known inhibitors of P-glycoprotein (P-gp). Mixed micelles prepared from Poloxamer 407 and TPGS may increase the therapeutic efficacy of the drug by d...
متن کاملThermogelling properties of purified poloxamer 407
Poloxamers are triblock copolymers with a center block of hydrophobic polypropylene oxide (PPO) flanked by two hydrophilic polyethyleneoxide (PEO) blocks. Among this family of copolymers, poloxamer 407 is a non-ionic surfactant with reversible gelation properties above a particular polymer concentration and a particular temperature. Easy preparation of poloxamer 407 based sterile injectable for...
متن کاملMechanical, rheological and release behaviors of a poloxamer 407/ poloxamer 188/carbopol 940 thermosensitive composite hydrogel.
The aims of this study were to prepare a thermosensitive composite hydrogel (TCH) by mixing 24% (w/v) poloxamer 407 (P407), 16% (w/v) poloxamer 188 (P188) and 0.1% (w/v) carbopol 940 (C940), and to determine the effect of natural borneol/ (2-hydroxypropyl)-β-cyclodextrin (NB/HP-β-CD) inclusion complex on the phase transition temperature, mechanical, rheological properties, and release behaviors...
متن کاملRheological Properties of Poloxamer 407 Solutions and Gels
The main objective of this work is to characterize the rheological behavior of poloxamer 407 solutions and gels in various shear flow fields.
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ژورنال
عنوان ژورنال: BMC Proceedings
سال: 2014
ISSN: 1753-6561
DOI: 10.1186/1753-6561-8-s4-p75